Affibody Medical Investor Relations

First Long-Term Clinical Study of Izokibep Published


September 12, 2023

Solna, Sweden, September 12, 2023. The first publication outlining phase 2 efficacy and safety results from a long-term study of izokibep, a small biological IL-17A inhibitor, is now available online.

The article, “Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II randomized placebo-controlled double-blind dose-finding multicentre study including long-term treatment”, is published in the British Journal of Dermatology (BJD). The BJD is a top-ranked international journal in the field of dermatology.

“Data from this phase 2 study indicate that the investigational agent izokibep is well tolerated and efficacious in the treatment of moderate-to-severe plaque psoriasis,” said Nikolai Brun, Chief Medical Officer of Affibody. “Encouragingly, the demonstration of long-term safety and efficacy over 3 years of treatment not only validates the Affibody® platform for long-term dosing but also places izokibep among the very frontrunners in the IL-17 space. This paves the way for higher doses or more frequent dosing to further enhance response rates, including in patients with hard-to-treat disease manifestations.”
Citation and link to publication
Sascha Gerdes, Petra Staubach, Thomas Dirschka, Dieter Wetzel, Oliver Weirich, Johannes Niesmann, Rodrigo da Mota, Alex Rothhaar, Michael Ardabili, Gerda Vlasitz, Joachim Feldwisch, Lisa Osterling Koskinen, Sven Ohlman, Paul Peloso, Nikolai C. Brun, Fredrik Y. Frejd (2023): Izokibep for the treatment of moderate-to-severe plaque psoriasis: a phase II randomized, placebo-controlled, double-blinded, dose-finding multicentre study including long-term treatment, BJD Published online September 12, 2023. DOI: 10.1093/bjd/ljad186.
Open-access link:
About BJD and Oxford University Press
The British Journal of Dermatology is a top-ranked international dermatology journal, publishing the highest-quality research to advance the understanding and management of skin disease to improve patient outcomes. The BJD is one of the journals of the British Association of Dermatologists (BAD), the professional membership body for dermatologists in the UK.
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